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Carlos G. Reverte

Visiting Assistant Professor of Economics

Olmsted Hall Room 122
Phone: 845-437-7115

Contact Carlos Reverte

  • B.S. 1998. Biochemistry, University of Valencia (Valencia, Spain)
  • M.S. 2000. Plant Physiology, University of Valencia (Valencia, Spain)
  • Ph.D. 2003. Biology, Boston College

Research Interests

Critical aspects of animal cell behavior, such as cell-cycle transition, proliferation, and differentiation, require cell adhesion to the extracellular matrix (ECM) by cell surface receptors. My research aims to investigate the molecular mechanisms by which integrins, the major family of cell-ECM adhesion receptors, regulate adhesion-dependent cellular processes. My studies focus on beta1 integrins, the larger subfamily, and the role of the integrin beta1 cytoplasmic domain (beta1 tail) in modulating integrin function.

Previous work has revealed that integrin function relies on the interaction of the integrin cytoplasmic domains (tails) with the cell's cytoskeleton and signal transduction apparatus. The molecular aspects, however, remain mostly unknown. Using rodent and human cell lines, and a combination of biochemical, cellular and molecular genetics, my recent studies have revealed that integrin signaling regulates centrosome function, the assembly of a bipolar mitotic spindle, and cytokinesis. In addition, I have identified PKCdelta as an important regulator of centrosome function.

Future research will use similar experimental approaches to: elucidate the molecular aspects of integrin signaling to the centrosome; understand the role of integrins in mitosis and cell division; investigate the role of integrins in centrosome function, bipolar spindle assembly and cytokinesis in the context of more complex biological systems, such as the differentiation of rodent embryonic stem cells.

Teaching Interests

I currently teach Biol 106: Introduction to Biological Investigation, Biol 238: Principles of Genetics, and Biol 323: Advanced Cell Biology.

Selected Publications

  • Reverte CG, Benware A, Jones CW, LaFlamme SE. 2006. Perturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis. J Cell Biol. Aug 14; 174(4):491-7.
  • Reverte CG, Yuan L, Keady BT, Lacza C, Attfield KR, Mahon GM, Freeman B, Whitehead IP, Hake LE. 2003. XGef is a CPEB-interacting protein involved in Xenopus oocyte maturation. Dev Biol. Mar 15; 255(2):383-98.
  • Reverte CG, Ahearn MD, Hake LE. 2001. CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome. Dev Biol. Mar 15;231(2): 447-58.

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